Larkana is situated at the distance of 471 km from Karachi on the south bank of Ghar Canal. It is main home of the Indus Valley Civilization, Mohehjo-daro which is the largest archaelogical site and known as the largest settlements of the Indus Valley Civilization and also considered one of the oldest cities of the world. Mohenhojo-Daro is located 28 km away from Larkana in the south.
Larkana is famous due to Bhutto family, which is one of the main ruling family in Pakistan. Zulfiqar Ali Bhutto was the prime miniter of Pakistan and also was the founder of Pakistan Peoples Party.