Badin is located at the distance of 210 km from Karachi in Sindh province and was the center of ancient Indus Valley civilization. It is also accessible via Hyderabad. It lies on the east side of the Indus River. Badin is suitable for rice crop due to its swampy and fertile land. Badin is also known as Sugar State due to its production of sugar.
Dadu is located on Indus Highway N55, at the distance of 331 km from Karachi on the western bank of the Indus River.
The largest lake in Pakistan, Manchar Lake, is an important visiting place in Dadu and Gorakh Hill station is the only hill station in Sindh province, is also a great attraction for tourists.
Ghotki is located at a distance of 526 km from Karachi on the eastern bank of the Indus River. Ghotki is an industrial town and there are a number of important industries such as fertilizers, power plants, gas fields, sugar mills, etc.
Hyderabad is located at the distance of 150 km from Karachi on the junction of the Indus Highway and the National Highway, on the east bank of the Indus River at an altitude of 43 feet
Jacobabad is situated at the distance of 548 km from Karachi, which is accessed via Shikarpur by turning left from Sukkur on Indus Highway N5. It was named after General John Jacob in 1847. It is connecting point with Balochistan from the north of Sindh.
The climate of Jacobabad is extremely hot in summer and mild in winter.
Jamshoro is located on Indus Highway M9 at the distance of 150 km from Karachi and just 18 km from Hyderabad on the right bank of the Indus River. Jamshoro is the gateway to the Indus Valley Civilization.
Jamshoro is also famous for the historical site of Ranikot Fort near Sann, which is the largest fort in the world, covering 26 km in its circumference.
Jamshoro is also rich in minerals such as limestone, silica sand, silt, coal, etc.
Karachi, the capital of Sindh, the most populous city of Pakistan and has the largest area in Pakistan, is located on the shore of the Arabian Sea and on the western edge of the Indus River. It is the main business and financial hub of Pakistan having the head offices of all major industries and major banks in Pakistan and it is also considered as the main point of local as well as foreign transportation via sea by port of Karachi and Port Bin Qasim as well as through Karachi Airport.
Kashmore is situated at a distance of 588 km from Karachi on National Highway N5. Its importance is due to the connection with Punjab Province with Rahim Yar Khan district and also a connection point with Balochistan Province. It lies on the western side of the Indus River. Most of the Kashmore area is part of the Thar Desert, which is the homeland of wild desert animals.
It is located at the distance of 452km from Karachi on the Kharipur East Canal south of the Indus River. Khairpur is founded by Mir Sohrab Khan of the Talpur dynasty in 1783, served as a princely state at that time. Khairpur is famous due to Sufi mystic Sachal Sarmast, whose shrine is situated in Raniput.
Larkana is situated at a distance of 471km from Karachi on the south bank of the Ghar Canal. It is the main home of the Indus Valley Civilization, Mohehjo-Daro which is the largest archaeological site and known as the largest settlement of the Indus Valley Civilization and also considered one of the oldest cities of the world. Mohenhojo-Daro is located 28 km away from Larkana in the south.
Matiari is situated at the distance of 230km from Karachi on the bank of the Indus River, on the National Highway N5. Matiari is one of the oldest territories of Sindh province.
Matiari is famous for its Sindh dressing, Ajrak. Matiari is also famous for a number of religious scholars, educators, and intellectuals. Shah Abdul Latif Bhitai, a great Sufi poet, was belonged to Matiari.
Qambar Shahdadkot is situated at a distance of 456 km from Karachi in Sindh Province. It has a mixture of multiple types of lands such as plains, agricultural land, the mountain range of Kirthar, and a number of lakes. The Kirthar range extends for almost 300 kilometers from the Mula River in Balochistan to Cape Muari in the Arabian Sea, Karachi.
Sanghar is situated at a distance of 302km from Karachi and accessible via Hyderabad on National Highway N120. It is the largest district of Sindh Province and has a boundary with India. There are some historical places such as the tomb of Mir Shahdad Talpur in Shahpur Chakar and Mansura, rains from the seventh century A.D.
Shaheed Benazirabad, also known as Nawabshah, is located at a distance of 293km from Karachi. It is accessed via Indus Highway N5 by turning right at Sakrand on Sakrand-Benazirabad Highway.
Shikarpur is located at the distance of 502 km from Karachi and accessible via Sukkur on the National Highway N65. Shikarpur is one of the districts formed by the British Government in Sindh Province. Shikarpur is a historical city and was enclosed within a fort that has seven gates.
Sujawal is situated on the left bank of the Indus River at the distance of 130 km from Karachi and is accessible via Thatta on Sujawal-Thatta Road. It is an agricultural town and producing a number of cash crops. Keti Bunder South Wildlife Sanctuary is along the Indus Delta for the protection of different wild animals, sea life, and birds.
Sukkur is situated in Sindh Province on the west bank of the Indus River at an altitude of 220 feet from sea level. At the Sukkur, the River Indus flows into its narrowest channel in the lower Indus course.
Tando Allahyar is located at a distance of 200 km from Karachi and accessible via Hyderabad on the National Highway N120. Tando Allahyar is an agricultural town and famous for the best quality of mangoes as well as cash crops such as sugarcane, wheat, and cotton. It is one of the largest producing of agricultural commodities in Pakistan.
Tando Muhammad Khan is situated at a distance of 193km from Karachi on the bank of Phuleli Canal and accessible by turning left from Jhirk on the National Highway N5 on the Tando Muhammad Khan-Mirpur Bathoro Road.
Tharparkar is a district with the border of India in Sindh Province, situated at a distance of 407km from Karachi and is accessible via Mirpur Khas on the National Highway N120. It is the largest district by area in Sindh Province and the least developed district in Sindh. Most of the area of Tharparkar is part of the Thar Desert.
Thatta is located on the bank of the Indus River at the distance of 103 km from Karachi on the National Highway N5. It is an historical city of Sindh and was the medieval capital of Sindh in different dynasties of the past.
Umerkot is situated at a distance of 308km from Karachi and is accessible via Mirpur Khas on the National Highway N120. Umerkot has its importance due to the birthplace of Akbar, the Mughal Emperor, in Umerkot Fort.